Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0312216
PubChem CID
Molecular Formula
C8H6N4OS
Molecular Weight
206.23 g/mol
Synonyms/Alias
[51987-99-6; TGN-020; n-(1;3;4-thiadiazol-2-yl)nicotinamide; N-(1;3;4-thiadiazol-2-yl)pyridine-3-carboxamide; N-(1;3;4-THIADIAZOLYL)NICOTINAMIDE; TGN 020; N-1;3;4-Thiadiazol-2-yl-3-pyridinecarboxamide...
InChI Key
AGEGZHOPKZFKBP-UHFFFAOYSA-N
InChI
InChI=1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)
IUPAC Name
N-(1,3,4-thiadiazol-2-yl)pyridine-3-carboxamide
CAS Number
N/A (Not available)

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

14 15 0 0 0 0 0 0 0 0999 V2000
4.1005 -0.9841 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
2.6291 -1.2759 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
1.6408 -0...

Experimental Data

Activity Data

Target Ion Channel
Aquaporin-4
Uniprot Accession Number
Function
Inhibitor
Species
Rattus norvegicus (Rat)
IC50
IC50: 3500 nM
EC50
N/A (Not available)
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
pH 7.4
Holding Potential
Not mention mV
Temperature
Not mention
Test Method
Patch-clamping
Test Species
Xenopus laevis oocyte

Binding Information

Binding Site
Transmembrane domain
Binding Site Residue
Not specified

Disease Information

Related Disease
Not specified

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
14
Rotatable Bonds
2
logP
1.1854
Complexity
52.0992
TPSA (Ų)
67.77
H-Bond Donors
1
H-Bond Acceptors
5
Ring Count
2
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